Drug interactions
Dalteparin + Nintedanib
Severity: Moderate
Dalteparin and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib inhibits VEGFR signalling and has been associated with bleeding events. Therapeutic anticoagulation with dalteparin can add to that risk.
What this interaction means in plain words
Dalteparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Additive bleeding risk from VEGFR inhibition by nintedanib and anticoagulation by dalteparin.
What to do
Use full-dose anticoagulation only when clearly needed and monitor for bleeding. Reassess the combination if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Dalteparin with Nintedanib?
MediHelp rates the interaction as moderate. Dalteparin and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nintedanib inhibits VEGFR signalling and has been associated with bleeding events. Therapeutic anticoagulation with dalteparin can add to that risk.
How serious is the interaction between Dalteparin and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use full-dose anticoagulation only when clearly needed and monitor for bleeding. Reassess the combination if bleeding occurs.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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