Drug interactions
Danicopan + Digoxin
Severity: Moderate
Danicopan and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase plasma concentrations of digoxin. This may lead to digoxin toxicity, including arrhythmias and gastrointestinal or visual symptoms.
What this interaction means in plain words
Danicopan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Digoxin belongs to Cardiovascular.
Why it happens
Danicopan inhibits intestinal and renal P-glycoprotein efflux, increasing digoxin absorption and reducing its elimination.
What to do
Check digoxin levels before and during co-administration and consider reducing the digoxin dose. Monitor for signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Digoxin?
MediHelp rates the interaction as moderate. Danicopan and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can increase plasma concentrations of digoxin. This may lead to digoxin toxicity, including arrhythmias and gastrointestinal or visual symptoms.
How serious is the interaction between Danicopan and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin levels before and during co-administration and consider reducing the digoxin dose. Monitor for signs of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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