Drug interactions
Danicopan + Eletriptan
Severity: Moderate
Danicopan and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to eletriptan, a P-gp substrate. The rise is probably modest but may increase triptan adverse effects.
What this interaction means in plain words
Danicopan and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of intestinal P-gp efflux, increasing eletriptan absorption.
What to do
Start with the lowest eletriptan dose and monitor for hypertension, chest tightness and dizziness. Consider another triptan if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Eletriptan?
MediHelp rates the interaction as moderate. Danicopan and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase exposure to eletriptan, a P-gp substrate. The rise is probably modest but may increase triptan adverse effects.
How serious is the interaction between Danicopan and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest eletriptan dose and monitor for hypertension, chest tightness and dizziness. Consider another triptan if effects are troublesome.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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