Drug interactions
Danicopan + Loratadine
Severity: Minor
Danicopan and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may raise exposure to loratadine, a P-gp substrate. Because loratadine has a wide safety margin, the increase is unlikely to cause serious harm but may add mild antihistaminic adverse effects such as sedation or headache.
What this interaction means in plain words
Danicopan and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Loratadine belongs to Respiratory.
Why it happens
Danicopan inhibits intestinal P-glycoprotein efflux, increasing loratadine absorption and exposure.
What to do
No dose change is usually needed; watch for increased drowsiness or headache and consider a lower loratadine dose or an alternative antihistamine if troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Danicopan and Loratadine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Loratadine?
MediHelp rates the interaction as minor. Danicopan and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may raise exposure to loratadine, a P-gp substrate. Because loratadine has a wide safety margin, the increase is unlikely to cause serious harm but may add mild antihistaminic adverse effects such as sedation or headache.
How serious is the interaction between Danicopan and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for increased drowsiness or headache and consider a lower loratadine dose or an alternative antihistamine if troublesome.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
