Drug interactions
Danicopan + Ondansetron
Severity: Minor
Danicopan and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ondansetron is only partly handled by P-gp, so the effect is probably modest, but higher exposure adds to its dose-related QT effect.
What this interaction means in plain words
Danicopan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
P-glycoprotein inhibition by danicopan may increase ondansetron absorption.
What to do
No routine adjustment is needed. Use the lowest effective ondansetron dose and consider an ECG in patients at risk of QT prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Ondansetron?
MediHelp rates the interaction as minor. Danicopan and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Ondansetron is only partly handled by P-gp, so the effect is probably modest, but higher exposure adds to its dose-related QT effect.
How serious is the interaction between Danicopan and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Use the lowest effective ondansetron dose and consider an ECG in patients at risk of QT prolongation.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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