Drug interactions
Danicopan + Risperidone
Severity: Moderate
Danicopan and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may raise plasma concentrations of P-gp substrates such as risperidone. This could amplify dose-related adverse effects including sedation, orthostasis and extrapyramidal symptoms.
What this interaction means in plain words
Danicopan and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Risperidone belongs to Central Nervous System.
Why it happens
Danicopan inhibits intestinal and cellular P-gp efflux, increasing risperidone exposure.
What to do
Monitor for risperidone adverse effects when danicopan is started. Consider a lower risperidone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Risperidone?
MediHelp rates the interaction as moderate. Danicopan and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may raise plasma concentrations of P-gp substrates such as risperidone. This could amplify dose-related adverse effects including sedation, orthostasis and extrapyramidal symptoms.
How serious is the interaction between Danicopan and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for risperidone adverse effects when danicopan is started. Consider a lower risperidone dose if toxicity develops.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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