Drug interactions
Danicopan + Sofosbuvir
Severity: Minor
Danicopan and Sofosbuvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP, both of which limit intestinal absorption of sofosbuvir. Coadministration may increase sofosbuvir exposure, though sofosbuvir's wide safety margin makes this of limited concern.
What this interaction means in plain words
Danicopan and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Sofosbuvir belongs to Anti Virals.
Why it happens
Danicopan inhibits intestinal P-gp and BCRP efflux, increasing sofosbuvir absorption.
What to do
No dose adjustment is generally required. Monitor for sofosbuvir adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Sofosbuvir?
MediHelp rates the interaction as minor. Danicopan and Sofosbuvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-gp and BCRP, both of which limit intestinal absorption of sofosbuvir. Coadministration may increase sofosbuvir exposure, though sofosbuvir's wide safety margin makes this of limited concern.
How serious is the interaction between Danicopan and Sofosbuvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required. Monitor for sofosbuvir adverse effects.
What other medicines interact with Sofosbuvir?
MediHelp also lists interactions of Sofosbuvir with, for example, Amiodarone, Apalutamide, Carbamazepine. The full list is on the Sofosbuvir page.
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