Drug interactions
Dantrolene + Fedratinib
Severity: Moderate
Dantrolene and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and may raise dantrolene concentrations. Higher dantrolene exposure could increase sedation, weakness and the risk of liver injury.
What this interaction means in plain words
Dantrolene and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Fedratinib belongs to Oncology.
Why it happens
Fedratinib inhibits CYP3A4, reducing dantrolene metabolism.
What to do
Monitor for sedation, muscle weakness and liver enzyme elevations, and lower the dantrolene dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Dantrolene with Fedratinib?
MediHelp rates the interaction as moderate. Dantrolene and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and may raise dantrolene concentrations. Higher dantrolene exposure could increase sedation, weakness and the risk of liver injury.
How serious is the interaction between Dantrolene and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, muscle weakness and liver enzyme elevations, and lower the dantrolene dose if adverse effects appear.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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