Drug interactions
Dantrolene + Fenfluramine
Severity: Minor
Dantrolene and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and fatigue in some patients, and dantrolene is also sedating. Any combined effect is likely modest, but additive drowsiness is possible.
What this interaction means in plain words
Dantrolene and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Fenfluramine belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; no specific mechanism has been established.
What to do
Monitor for drowsiness and counsel patients about driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Dantrolene with Fenfluramine?
MediHelp rates the interaction as minor. Dantrolene and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine can cause somnolence and fatigue in some patients, and dantrolene is also sedating. Any combined effect is likely modest, but additive drowsiness is possible.
How serious is the interaction between Dantrolene and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and counsel patients about driving until the response is known.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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