Drug interactions
Dantrolene + Idelalisib
Severity: Moderate
Dantrolene and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may raise dantrolene concentrations. This may increase sedation, weakness and hepatotoxicity, and idelalisib itself carries hepatotoxicity risk.
What this interaction means in plain words
Dantrolene and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by idelalisib may reduce dantrolene metabolism.
What to do
Monitor liver enzymes and for excessive sedation or weakness, and reduce dantrolene dose if needed. Consider an alternative antispasticity agent for chronic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Dantrolene with Idelalisib?
MediHelp rates the interaction as moderate. Dantrolene and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may raise dantrolene concentrations. This may increase sedation, weakness and hepatotoxicity, and idelalisib itself carries hepatotoxicity risk.
How serious is the interaction between Dantrolene and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for excessive sedation or weakness, and reduce dantrolene dose if needed. Consider an alternative antispasticity agent for chronic use.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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