Drug interactions
Dantrolene + Levoketoconazole
Severity: Moderate
Dantrolene and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may increase dantrolene exposure. Both drugs can cause hepatotoxicity, so combined use raises liver injury concern.
What this interaction means in plain words
Dantrolene and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition may reduce dantrolene metabolism, with additive hepatotoxic potential.
What to do
Monitor liver function tests closely at baseline and regularly during coadministration. Consider reducing the dantrolene dose if weakness or sedation increases, and stop if liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dantrolene with Levoketoconazole?
MediHelp rates the interaction as moderate. Dantrolene and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may increase dantrolene exposure. Both drugs can cause hepatotoxicity, so combined use raises liver injury concern.
How serious is the interaction between Dantrolene and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests closely at baseline and regularly during coadministration. Consider reducing the dantrolene dose if weakness or sedation increases, and stop if liver injury develops.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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