Drug interactions
Dantrolene + Mirtazapine
Severity: Moderate
Dantrolene and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is a sedating antidepressant, particularly at lower doses, and dantrolene also causes drowsiness. Together they may increase sedation and impair alertness.
What this interaction means in plain words
Dantrolene and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects, with mirtazapine adding H1-antihistamine sedation.
What to do
Monitor for oversedation and falls, especially at initiation. Take mirtazapine at night and counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Dantrolene with Mirtazapine?
MediHelp rates the interaction as moderate. Dantrolene and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is a sedating antidepressant, particularly at lower doses, and dantrolene also causes drowsiness. Together they may increase sedation and impair alertness.
How serious is the interaction between Dantrolene and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, especially at initiation. Take mirtazapine at night and counsel patients about driving.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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