Drug interactions
Dantrolene + Stiripentol
Severity: Moderate
Dantrolene and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and somnolence, so combined use can produce additive CNS depression. Stiripentol also modulates CYP3A4, and dantrolene is partly metabolized by hepatic oxidation, so dantrolene exposure could change, though this is less well characterized.
What this interaction means in plain words
Dantrolene and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, plus possible CYP3A4 inhibition or induction by stiripentol altering dantrolene exposure.
What to do
Monitor for excessive sedation, drowsiness and reduced muscle tone, and reduce the dose of either drug if impairment develops. Advise patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Stiripentol
Frequently asked questions
Can I take Dantrolene with Stiripentol?
MediHelp rates the interaction as moderate. Dantrolene and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and somnolence, so combined use can produce additive CNS depression. Stiripentol also modulates CYP3A4, and dantrolene is partly metabolized by hepatic oxidation, so dantrolene exposure could change, though this is less well characterized.
How serious is the interaction between Dantrolene and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, drowsiness and reduced muscle tone, and reduce the dose of either drug if impairment develops. Advise patients to avoid alcohol and other sedatives.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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