Drug interactions
Dantrolene + Tramadol
Severity: Moderate
Dantrolene and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and muscle weakness, and these effects add to opioid sedation and respiratory depression. Patients may have impaired alertness and, with higher doses, reduced ventilation.
What this interaction means in plain words
Dantrolene and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle weakness.
What to do
Monitor sedation and respiratory status, and start with lower doses of tramadol. Counsel patients on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Tramadol?
MediHelp rates the interaction as moderate. Dantrolene and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness and muscle weakness, and these effects add to opioid sedation and respiratory depression. Patients may have impaired alertness and, with higher doses, reduced ventilation.
How serious is the interaction between Dantrolene and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and start with lower doses of tramadol. Counsel patients on driving and operating machinery.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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