Drug interactions
Dantrolene + Trazodone
Severity: Moderate
Dantrolene and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is a sedating antidepressant and dantrolene can cause drowsiness. Used together they may cause more sedation, dizziness and psychomotor impairment.
What this interaction means in plain words
Dantrolene and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excessive sedation and orthostatic dizziness, especially in older adults. Advise caution with driving until response is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Dantrolene with Trazodone?
MediHelp rates the interaction as moderate. Dantrolene and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is a sedating antidepressant and dantrolene can cause drowsiness. Used together they may cause more sedation, dizziness and psychomotor impairment.
How serious is the interaction between Dantrolene and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic dizziness, especially in older adults. Advise caution with driving until response is established.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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