Drug interactions
Dantrolene + Trimipramine
Severity: Moderate
Dantrolene and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a strongly sedating tricyclic antidepressant and dantrolene also causes drowsiness. Together they may produce additive sedation and impaired alertness.
What this interaction means in plain words
Dantrolene and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and falls, and counsel on driving. Lower the dose of one agent if sedation interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Dantrolene with Trimipramine?
MediHelp rates the interaction as moderate. Dantrolene and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a strongly sedating tricyclic antidepressant and dantrolene also causes drowsiness. Together they may produce additive sedation and impaired alertness.
How serious is the interaction between Dantrolene and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and counsel on driving. Lower the dose of one agent if sedation interferes with function.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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