Drug interactions
Dapsone + Enzalutamide
Severity: Moderate
Dapsone and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may reduce dapsone exposure, potentially compromising efficacy. Increased formation of toxic metabolites is also possible.
What this interaction means in plain words
Dapsone and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases dapsone clearance.
What to do
Monitor treatment response and haemoglobin and methaemoglobin levels, and consider an alternative agent if efficacy is critical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Dapsone with Enzalutamide?
MediHelp rates the interaction as moderate. Dapsone and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and may reduce dapsone exposure, potentially compromising efficacy. Increased formation of toxic metabolites is also possible.
How serious is the interaction between Dapsone and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and haemoglobin and methaemoglobin levels, and consider an alternative agent if efficacy is critical.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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