Drug interactions
Dapsone + Nitisinone
Severity: Minor
Dapsone and Nitisinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, but dapsone is metabolized mainly by N-acetylation and CYP3A4/2C9 to a lesser degree. Any increase in dapsone exposure is likely small.
What this interaction means in plain words
Dapsone and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Nitisinone belongs to Miscellaneous.
Why it happens
Nitisinone inhibits CYP2C9, which may slightly reduce dapsone hydroxylation.
What to do
No empiric dose change is needed; monitor for methemoglobinemia or hemolysis if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Dapsone with Nitisinone?
MediHelp rates the interaction as minor. Dapsone and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9, but dapsone is metabolized mainly by N-acetylation and CYP3A4/2C9 to a lesser degree. Any increase in dapsone exposure is likely small.
How serious is the interaction between Dapsone and Nitisinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for methemoglobinemia or hemolysis if symptoms occur.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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