Drug interactions
Dapsone + Posaconazole
Severity: Minor
Dapsone and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and could increase dapsone exposure. Higher exposure may worsen hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency.
What this interaction means in plain words
Dapsone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated dapsone metabolism by posaconazole.
What to do
Monitor hemoglobin and symptoms of methemoglobinemia; consider dapsone dose reduction if toxicity emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dapsone with Posaconazole?
MediHelp rates the interaction as minor. Dapsone and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole is a strong CYP3A4 inhibitor and could increase dapsone exposure. Higher exposure may worsen hemolysis and methemoglobinemia, particularly in patients with G6PD deficiency.
How serious is the interaction between Dapsone and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and symptoms of methemoglobinemia; consider dapsone dose reduction if toxicity emerges.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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