Drug interactions
Daridorexant + Propofol
Severity: Moderate
Daridorexant and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is an orexin receptor antagonist hypnotic that causes sedation. Combined with propofol, CNS depression is additive and may lead to deeper sedation than expected.
What this interaction means in plain words
Daridorexant and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression via different sedative mechanisms.
What to do
Titrate propofol cautiously to clinical effect and monitor sedation depth and respiration. Tell the anesthesia team about recent daridorexant use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Propofol?
MediHelp rates the interaction as moderate. Daridorexant and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant is an orexin receptor antagonist hypnotic that causes sedation. Combined with propofol, CNS depression is additive and may lead to deeper sedation than expected.
How serious is the interaction between Daridorexant and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously to clinical effect and monitor sedation depth and respiration. Tell the anesthesia team about recent daridorexant use.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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