Drug interactions
Darolutamide + Tenofovir alafenamide
Severity: Minor
Darolutamide and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP and P-gp-related transport, which can increase intestinal absorption of tenofovir alafenamide. The expected rise in tenofovir exposure is likely modest and of limited clinical consequence.
What this interaction means in plain words
Darolutamide and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darolutamide belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Inhibition of intestinal BCRP (and possibly P-gp) efflux by darolutamide, increasing tenofovir alafenamide absorption.
What to do
No routine dose adjustment is required. Monitor renal function and tenofovir-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Darolutamide and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darolutamide inhibits BCRP and P-gp-related transport, which can increase intestinal absorption of tenofovir alafenamide. The expected rise in tenofovir exposure is likely modest and of limited clinical consequence.
How serious is the interaction between Darolutamide and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is required. Monitor renal function and tenofovir-related adverse effects.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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