Drug interactions
Darunavir + Enzalutamide
Severity: Major
Darunavir and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is expected to reduce darunavir concentrations, risking virologic failure and resistance. Boosted darunavir regimens contain a CYP3A inhibitor that may raise enzalutamide exposure.
What this interaction means in plain words
Darunavir and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4 and lowers darunavir exposure, while ritonavir or cobicistat boosting inhibits CYP3A4 and may raise enzalutamide levels.
What to do
Avoid the combination and use an alternative antiretroviral regimen. If unavoidable, monitor HIV viral load and reduce the enzalutamide dose as labeled.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Enzalutamide?
MediHelp rates the interaction as major. Darunavir and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is expected to reduce darunavir concentrations, risking virologic failure and resistance. Boosted darunavir regimens contain a CYP3A inhibitor that may raise enzalutamide exposure.
How serious is the interaction between Darunavir and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiretroviral regimen. If unavoidable, monitor HIV viral load and reduce the enzalutamide dose as labeled.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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