Drug interactions
Darunavir + Medroxyprogesterone
Severity: Moderate
Darunavir and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir- or cobicistat-boosted darunavir may alter progestin exposure and weaken hormonal contraception. The effect on depot medroxyprogesterone is considered small, so oral use is of more concern.
What this interaction means in plain words
Darunavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Medroxyprogesterone belongs to Endocrine.
Why it happens
Boosted darunavir regimens can alter hepatic metabolism of progestins; the exact mechanism for medroxyprogesterone is not well established.
What to do
Add a barrier method when oral medroxyprogesterone is used for contraception with boosted darunavir. Injectable or intrauterine options are generally preferable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Darunavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir- or cobicistat-boosted darunavir may alter progestin exposure and weaken hormonal contraception. The effect on depot medroxyprogesterone is considered small, so oral use is of more concern.
How serious is the interaction between Darunavir and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a barrier method when oral medroxyprogesterone is used for contraception with boosted darunavir. Injectable or intrauterine options are generally preferable.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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