Drug interactions
Darunavir + Metoclopramide
Severity: Moderate
Darunavir and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster such as ritonavir or cobicistat, may modestly raise metoclopramide exposure through CYP2D6 inhibition. Darunavir itself is not a strong CYP2D6 inhibitor, so the effect is probably small. Higher metoclopramide levels would increase extrapyramidal and sedative effects.
What this interaction means in plain words
Darunavir and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Possible CYP2D6 inhibition, mainly from the pharmacokinetic booster, reducing metoclopramide clearance.
What to do
Monitor for extrapyramidal symptoms and drowsiness and use the lowest effective metoclopramide dose. Limit treatment duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Metoclopramide?
MediHelp rates the interaction as moderate. Darunavir and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with a booster such as ritonavir or cobicistat, may modestly raise metoclopramide exposure through CYP2D6 inhibition. Darunavir itself is not a strong CYP2D6 inhibitor, so the effect is probably small. Higher metoclopramide levels would increase extrapyramidal and sedative effects.
How serious is the interaction between Darunavir and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and drowsiness and use the lowest effective metoclopramide dose. Limit treatment duration.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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