Drug interactions
Darunavir + Posaconazole
Severity: Moderate
Darunavir and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise darunavir concentrations because darunavir is a CYP3A4 substrate, an effect that is additive with its pharmacokinetic booster. Darunavir adverse effects such as rash, diarrhea and liver enzyme elevation may be more frequent.
What this interaction means in plain words
Darunavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of darunavir.
What to do
Monitor for darunavir adverse effects and liver function tests. Also monitor for posaconazole effects, as ritonavir or cobicistat-boosted regimens may increase posaconazole levels too.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Posaconazole?
MediHelp rates the interaction as moderate. Darunavir and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can raise darunavir concentrations because darunavir is a CYP3A4 substrate, an effect that is additive with its pharmacokinetic booster. Darunavir adverse effects such as rash, diarrhea and liver enzyme elevation may be more frequent.
How serious is the interaction between Darunavir and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darunavir adverse effects and liver function tests. Also monitor for posaconazole effects, as ritonavir or cobicistat-boosted regimens may increase posaconazole levels too.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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