Drug interactions
Dasatinib + Disopyramide
Severity: Major
Dasatinib and Disopyramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic with well-established torsades de pointes risk, and dasatinib also prolongs the QT interval. Together the risk of serious ventricular arrhythmia is increased.
What this interaction means in plain words
Dasatinib and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Disopyramide belongs to Cardiovascular.
Why it happens
Additive QT prolongation by blockade of cardiac repolarizing potassium currents.
What to do
Avoid the combination and use a non-QT-prolonging antiarrhythmic strategy when possible. If unavoidable, monitor the ECG closely and maintain normal potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Dasatinib with Disopyramide?
MediHelp rates the interaction as major. Dasatinib and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic with well-established torsades de pointes risk, and dasatinib also prolongs the QT interval. Together the risk of serious ventricular arrhythmia is increased.
How serious is the interaction between Dasatinib and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antiarrhythmic strategy when possible. If unavoidable, monitor the ECG closely and maintain normal potassium and magnesium.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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