Drug interactions
Dasatinib + Pentamidine
Severity: Major
Dasatinib and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Added to dasatinib, which also has QT-prolonging potential, the arrhythmia risk is increased.
What this interaction means in plain words
Dasatinib and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of the QT interval through effects on cardiac repolarization.
What to do
Consider alternative antimicrobial prophylaxis or treatment, such as an inhaled route for pentamidine. If both are required, monitor ECG and correct electrolyte disturbances.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Dasatinib with Pentamidine?
MediHelp rates the interaction as major. Dasatinib and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Added to dasatinib, which also has QT-prolonging potential, the arrhythmia risk is increased.
How serious is the interaction between Dasatinib and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative antimicrobial prophylaxis or treatment, such as an inhaled route for pentamidine. If both are required, monitor ECG and correct electrolyte disturbances.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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