Drug interactions
Dasatinib + Posaconazole
Severity: Major
Dasatinib and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is metabolized mainly by CYP3A4, and posaconazole can substantially raise its concentrations, increasing myelosuppression, fluid retention and bleeding risk. Both drugs also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Dasatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of dasatinib, and both drugs have additive QT-prolonging effects.
What to do
Prefer an alternative antifungal without strong CYP3A4 inhibition; if combined, reduce the dasatinib dose per labeling and monitor ECG, electrolytes and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Posaconazole?
MediHelp rates the interaction as major. Dasatinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib is metabolized mainly by CYP3A4, and posaconazole can substantially raise its concentrations, increasing myelosuppression, fluid retention and bleeding risk. Both drugs also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Dasatinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antifungal without strong CYP3A4 inhibition; if combined, reduce the dasatinib dose per labeling and monitor ECG, electrolytes and blood counts.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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