Drug interactions
Dasatinib + Tucatinib
Severity: Moderate
Dasatinib and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor and may increase dasatinib exposure. Higher levels raise the risk of dasatinib toxicities such as myelosuppression, effusions and QT prolongation.
What this interaction means in plain words
Dasatinib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of dasatinib by tucatinib.
What to do
Avoid if possible; otherwise consider reducing the dasatinib dose and monitor blood counts, fluid status and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Dasatinib with Tucatinib?
MediHelp rates the interaction as moderate. Dasatinib and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a CYP3A inhibitor and may increase dasatinib exposure. Higher levels raise the risk of dasatinib toxicities such as myelosuppression, effusions and QT prolongation.
How serious is the interaction between Dasatinib and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise consider reducing the dasatinib dose and monitor blood counts, fluid status and ECG.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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