Drug interactions
Delafloxacin + Sucralfate
Severity: Moderate
Delafloxacin and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminium, which chelates oral delafloxacin and reduces absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Delafloxacin and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Chelation of delafloxacin by aluminium in the gut lowers its oral bioavailability.
What to do
Give oral delafloxacin at least 2 hours before or 6 hours after sucralfate. Use intravenous delafloxacin if separation is not possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Frequently asked questions
Can I take Delafloxacin with Sucralfate?
MediHelp rates the interaction as moderate. Delafloxacin and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminium, which chelates oral delafloxacin and reduces absorption. This may result in subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Delafloxacin and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after sucralfate. Use intravenous delafloxacin if separation is not possible.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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