Drug interactions
Denosumab + Lomustine
Severity: Moderate
Denosumab and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes delayed and prolonged myelosuppression, and denosumab has been associated with serious infections. Together they may increase infection risk over several weeks.
What this interaction means in plain words
Denosumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Lomustine belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: nitrosourea bone marrow suppression plus RANKL inhibition affecting immunity.
What to do
Monitor blood counts through the expected nadir and watch for infection. Treat fever or suspected infection early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Denosumab with Lomustine?
MediHelp rates the interaction as moderate. Denosumab and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes delayed and prolonged myelosuppression, and denosumab has been associated with serious infections. Together they may increase infection risk over several weeks.
How serious is the interaction between Denosumab and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts through the expected nadir and watch for infection. Treat fever or suspected infection early.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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