Drug interactions
Desflurane + Disopyramide
Severity: Major
Desflurane and Disopyramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and can cause torsades de pointes. Desflurane adds QT prolongation, and disopyramide's negative inotropic effect may worsen anesthetic-related hypotension.
What this interaction means in plain words
Desflurane and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desflurane belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
Why it happens
Additive QT prolongation through delayed cardiac repolarization, with additive negative inotropic and hypotensive effects.
What to do
Obtain an ECG and correct potassium and magnesium before anesthesia. Monitor the ECG and blood pressure continuously and have defibrillation available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Desflurane with Disopyramide?
MediHelp rates the interaction as major. Desflurane and Disopyramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and can cause torsades de pointes. Desflurane adds QT prolongation, and disopyramide's negative inotropic effect may worsen anesthetic-related hypotension.
How serious is the interaction between Desflurane and Disopyramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and correct potassium and magnesium before anesthesia. Monitor the ECG and blood pressure continuously and have defibrillation available.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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