Drug interactions
Desflurane + Metoclopramide
Severity: Moderate
Desflurane and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide may reduce the anesthetic requirement and enhance sedation with inhaled anesthetics. Together there may be deeper sedation and hemodynamic effects during anesthesia.
What this interaction means in plain words
Desflurane and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Anesthesia providers should titrate desflurane to clinical effect and monitor depth of anesthesia and hemodynamics. Metoclopramide can be used perioperatively with usual monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Metoclopramide?
MediHelp rates the interaction as moderate. Desflurane and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide may reduce the anesthetic requirement and enhance sedation with inhaled anesthetics. Together there may be deeper sedation and hemodynamic effects during anesthesia.
How serious is the interaction between Desflurane and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Anesthesia providers should titrate desflurane to clinical effect and monitor depth of anesthesia and hemodynamics. Metoclopramide can be used perioperatively with usual monitoring.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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