Drug interactions
Desflurane + Prochlorperazine
Severity: Moderate
Desflurane and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane is an inhaled anesthetic that produces dose-dependent CNS and cardiovascular depression, and prochlorperazine adds sedation and hypotension. Both can influence QT interval, although the net effect is variable.
What this interaction means in plain words
Desflurane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS and cardiovascular depression; both agents may alter ventricular repolarization.
What to do
Inform the anesthesia team of prochlorperazine use and monitor blood pressure and ECG during anesthesia. Adjust anesthetic depth as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Prochlorperazine?
MediHelp rates the interaction as moderate. Desflurane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane is an inhaled anesthetic that produces dose-dependent CNS and cardiovascular depression, and prochlorperazine adds sedation and hypotension. Both can influence QT interval, although the net effect is variable.
How serious is the interaction between Desflurane and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of prochlorperazine use and monitor blood pressure and ECG during anesthesia. Adjust anesthetic depth as needed.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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