Drug interactions
Desipramine + Dexmethylphenidate
Severity: Moderate
Desipramine and Dexmethylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate may raise tricyclic antidepressant levels by inhibiting metabolism, and both agents increase noradrenergic activity. This may cause hypertension, tachycardia and arrhythmia.
What this interaction means in plain words
Desipramine and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dexmethylphenidate belongs to Central Nervous System.
Why it happens
Additive noradrenergic effects, with possible inhibition of tricyclic metabolism by methylphenidate.
What to do
Monitor blood pressure, heart rate and ECG when starting or adjusting either drug. Consider lowering the desipramine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Desipramine with Dexmethylphenidate?
MediHelp rates the interaction as moderate. Desipramine and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmethylphenidate may raise tricyclic antidepressant levels by inhibiting metabolism, and both agents increase noradrenergic activity. This may cause hypertension, tachycardia and arrhythmia.
How serious is the interaction between Desipramine and Dexmethylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when starting or adjusting either drug. Consider lowering the desipramine dose if adverse effects occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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