Drug interactions
Desipramine + Givosiran
Severity: Moderate
Desipramine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can raise exposure to sensitive CYP2D6 substrates such as desipramine. Higher desipramine levels increase the risk of anticholinergic effects, sedation and cardiac conduction abnormalities.
What this interaction means in plain words
Desipramine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing desipramine metabolism.
What to do
Monitor for desipramine toxicity and consider reducing its dose as per labeling, guided by plasma level and ECG. Choose a non-CYP2D6-dependent agent if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Givosiran, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Desipramine with Givosiran?
MediHelp rates the interaction as moderate. Desipramine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can raise exposure to sensitive CYP2D6 substrates such as desipramine. Higher desipramine levels increase the risk of anticholinergic effects, sedation and cardiac conduction abnormalities.
How serious is the interaction between Desipramine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for desipramine toxicity and consider reducing its dose as per labeling, guided by plasma level and ECG. Choose a non-CYP2D6-dependent agent if feasible.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
