Drug interactions
Desloratadine + Metoclopramide
Severity: Minor
Desloratadine and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desloratadine is non-sedating at usual doses, so any additive drowsiness with metoclopramide is slight. No important interaction is expected clinically.
What this interaction means in plain words
Desloratadine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Possible slight additive central nervous system effects; no established mechanism.
What to do
No dose adjustment is needed. Advise the patient to report unusual drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Frequently asked questions
Can I take Desloratadine with Metoclopramide?
MediHelp rates the interaction as minor. Desloratadine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desloratadine is non-sedating at usual doses, so any additive drowsiness with metoclopramide is slight. No important interaction is expected clinically.
How serious is the interaction between Desloratadine and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Advise the patient to report unusual drowsiness.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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