Drug interactions
Dexchlorpheniramine + Lisdexamfetamine
Severity: Minor
Dexchlorpheniramine and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine, while lisdexamfetamine is a stimulant. The stimulant may partly offset drowsiness but does not reliably reverse impaired performance. Effects vary between patients.
What this interaction means in plain words
Dexchlorpheniramine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexchlorpheniramine belongs to Respiratory; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects of histamine H1 blockade and amphetamine-induced catecholamine release.
What to do
No routine adjustment is needed; monitor for sedation or stimulation and counsel patients about unpredictable alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Lisdexamfetamine?
MediHelp rates the interaction as minor. Dexchlorpheniramine and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating antihistamine, while lisdexamfetamine is a stimulant. The stimulant may partly offset drowsiness but does not reliably reverse impaired performance. Effects vary between patients.
How serious is the interaction between Dexchlorpheniramine and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for sedation or stimulation and counsel patients about unpredictable alertness.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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