Drug interactions
Dexchlorpheniramine + Metoclopramide
Severity: Moderate
Dexchlorpheniramine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so the combination may increase sedation and impair concentration. The anticholinergic activity of the antihistamine may also blunt the prokinetic effect of metoclopramide.
What this interaction means in plain words
Dexchlorpheniramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexchlorpheniramine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and anticholinergic antagonism of gastrointestinal motility effects.
What to do
Monitor for sedation and reduced gastrointestinal response. Advise the patient to avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Metoclopramide?
MediHelp rates the interaction as moderate. Dexchlorpheniramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so the combination may increase sedation and impair concentration. The anticholinergic activity of the antihistamine may also blunt the prokinetic effect of metoclopramide.
How serious is the interaction between Dexchlorpheniramine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and reduced gastrointestinal response. Advise the patient to avoid driving if drowsy.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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