Drug interactions
Dexmedetomidine + Metoclopramide
Severity: Moderate
Dexmedetomidine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist that can cause hypotension and bradycardia, and metoclopramide may add sedation. Together they may produce deeper sedation than expected.
What this interaction means in plain words
Dexmedetomidine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Titrate dexmedetomidine to the desired sedation level and monitor blood pressure, heart rate and sedation depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Metoclopramide?
MediHelp rates the interaction as moderate. Dexmedetomidine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist that can cause hypotension and bradycardia, and metoclopramide may add sedation. Together they may produce deeper sedation than expected.
How serious is the interaction between Dexmedetomidine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to the desired sedation level and monitor blood pressure, heart rate and sedation depth.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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