Drug interactions
Dexmedetomidine + Prochlorperazine
Severity: Moderate
Dexmedetomidine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can deepen sedation and prolong recovery. Hypotension and bradycardia from dexmedetomidine may also be amplified by the alpha-blocking effect of prochlorperazine.
What this interaction means in plain words
Dexmedetomidine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with additive hypotensive effects through alpha-adrenergic blockade and sympatholysis.
What to do
Titrate dexmedetomidine to sedation score and consider a lower starting dose. Monitor blood pressure and heart rate continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Prochlorperazine?
MediHelp rates the interaction as moderate. Dexmedetomidine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can deepen sedation and prolong recovery. Hypotension and bradycardia from dexmedetomidine may also be amplified by the alpha-blocking effect of prochlorperazine.
How serious is the interaction between Dexmedetomidine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to sedation score and consider a lower starting dose. Monitor blood pressure and heart rate continuously.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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