Drug interactions
Dexmethylphenidate + Maprotiline
Severity: Moderate
Dexmethylphenidate and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate can raise tricyclic-type antidepressant levels and has additive sympathomimetic effects. This may cause hypertension, tachycardia, and lowering of the seizure threshold.
What this interaction means in plain words
Dexmethylphenidate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmethylphenidate belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive noradrenergic effects and possible reduced antidepressant metabolism.
What to do
Monitor blood pressure, heart rate and seizure risk, and lower the maprotiline dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Maprotiline?
MediHelp rates the interaction as moderate. Dexmethylphenidate and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmethylphenidate can raise tricyclic-type antidepressant levels and has additive sympathomimetic effects. This may cause hypertension, tachycardia, and lowering of the seizure threshold.
How serious is the interaction between Dexmethylphenidate and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and seizure risk, and lower the maprotiline dose if toxicity occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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