Drug interactions
DHEA + Sirolimus
Severity: Minor
DHEA and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA has no firmly established CYP3A4 inhibiting effect, so a change in sirolimus levels is theoretical. Sirolimus has a narrow therapeutic index, so any change in exposure could matter.
What this interaction means in plain words
DHEA and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Sirolimus belongs to Miscellaneous.
Why it happens
Possible minor CYP3A4 or P-gp modulation by DHEA; not established.
What to do
Check sirolimus trough levels if DHEA is started or stopped and adjust the dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take DHEA with Sirolimus?
MediHelp rates the interaction as minor. DHEA and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA has no firmly established CYP3A4 inhibiting effect, so a change in sirolimus levels is theoretical. Sirolimus has a narrow therapeutic index, so any change in exposure could matter.
How serious is the interaction between DHEA and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sirolimus trough levels if DHEA is started or stopped and adjust the dose accordingly.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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