Drug interactions
Diclofenac + Felbamate
Severity: Minor
Diclofenac and Felbamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits some CYP enzymes, including CYP2C19, and may raise levels of certain substrates. An effect on diclofenac via CYP2C9 is plausible but poorly documented.
What this interaction means in plain words
Diclofenac and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Felbamate belongs to Central Nervous System.
Why it happens
Possible felbamate inhibition of CYP2C9; not well established.
What to do
Use the lowest effective diclofenac dose and monitor for NSAID adverse effects such as dyspepsia or edema.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Diclofenac with Felbamate?
MediHelp rates the interaction as minor. Diclofenac and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits some CYP enzymes, including CYP2C19, and may raise levels of certain substrates. An effect on diclofenac via CYP2C9 is plausible but poorly documented.
How serious is the interaction between Diclofenac and Felbamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective diclofenac dose and monitor for NSAID adverse effects such as dyspepsia or edema.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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