Drug interactions
Dicloxacillin + Pacritinib
Severity: Moderate
Dicloxacillin and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin is a CYP3A4 inducer and pacritinib is a CYP3A4 substrate, so pacritinib exposure may fall and its effect on myelofibrosis may be reduced. Pacritinib labeling advises avoiding moderate or strong CYP3A4 inducers, and dicloxacillin's induction is weaker than that of classic inducers.
What this interaction means in plain words
Dicloxacillin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicloxacillin belongs to Anti Bacterial; Pacritinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by dicloxacillin increases pacritinib metabolism and lowers its plasma concentrations.
What to do
Where possible choose an alternative antibiotic that does not induce CYP3A4. If dicloxacillin is necessary, monitor spleen response and symptoms of pacritinib efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Dicloxacillin with Pacritinib?
MediHelp rates the interaction as moderate. Dicloxacillin and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a CYP3A4 inducer and pacritinib is a CYP3A4 substrate, so pacritinib exposure may fall and its effect on myelofibrosis may be reduced. Pacritinib labeling advises avoiding moderate or strong CYP3A4 inducers, and dicloxacillin's induction is weaker than that of classic inducers.
How serious is the interaction between Dicloxacillin and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative antibiotic that does not induce CYP3A4. If dicloxacillin is necessary, monitor spleen response and symptoms of pacritinib efficacy.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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