Drug interactions
Dicloxacillin + Ubrogepant
Severity: Moderate
Dicloxacillin and Ubrogepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin is reported to induce CYP3A4 weakly to moderately, and ubrogepant is a CYP3A4 substrate. Induction could lower ubrogepant exposure and reduce migraine relief. Labeling advises a higher ubrogepant dose with moderate or weak CYP3A4 inducers.
What this interaction means in plain words
Dicloxacillin and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicloxacillin belongs to Anti Bacterial; Ubrogepant belongs to Central Nervous System.
Why it happens
CYP3A4 induction by dicloxacillin increases the metabolism of ubrogepant.
What to do
Use the higher ubrogepant dose recommended in its labeling for CYP3A4 inducers, and review efficacy. Reassess if the antibiotic is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Other interactions of Ubrogepant
- Clarithromycin + Ubrogepant Contraindicated
- Itraconazole + Ubrogepant Contraindicated
- Ketoconazole + Ubrogepant Contraindicated
- Posaconazole + Ubrogepant Contraindicated
- Ubrogepant + Voriconazole Contraindicated
- Apalutamide + Ubrogepant Major
Frequently asked questions
Can I take Dicloxacillin with Ubrogepant?
MediHelp rates the interaction as moderate. Dicloxacillin and Ubrogepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is reported to induce CYP3A4 weakly to moderately, and ubrogepant is a CYP3A4 substrate. Induction could lower ubrogepant exposure and reduce migraine relief. Labeling advises a higher ubrogepant dose with moderate or weak CYP3A4 inducers.
How serious is the interaction between Dicloxacillin and Ubrogepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the higher ubrogepant dose recommended in its labeling for CYP3A4 inducers, and review efficacy. Reassess if the antibiotic is stopped.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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