Drug interactions
Dicyclomine + Metoclopramide
Severity: Moderate
Dicyclomine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an anticholinergic antispasmodic that slows GI motility and opposes the prokinetic action of metoclopramide. Metoclopramide may therefore be less effective.
What this interaction means in plain words
Dicyclomine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Pharmacodynamic antagonism between antimuscarinic blockade and cholinergic prokinetic stimulation.
What to do
Monitor for reduced response of nausea or gastroparesis symptoms. Avoid combining them when motility is the therapeutic target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Metoclopramide?
MediHelp rates the interaction as moderate. Dicyclomine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an anticholinergic antispasmodic that slows GI motility and opposes the prokinetic action of metoclopramide. Metoclopramide may therefore be less effective.
How serious is the interaction between Dicyclomine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response of nausea or gastroparesis symptoms. Avoid combining them when motility is the therapeutic target.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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