Drug interactions
Dicyclomine + Prochlorperazine
Severity: Moderate
Dicyclomine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Anticholinergics may also slow gastric motility and modestly reduce the absorption of oral phenothiazines.
What this interaction means in plain words
Dicyclomine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, with possible reduced oral phenothiazine absorption from slowed gastrointestinal motility.
What to do
Monitor for anticholinergic toxicity, particularly in older patients, and for reduced antiemetic or antipsychotic effect. Avoid combining where other options exist in patients with glaucoma, ileus or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Prochlorperazine?
MediHelp rates the interaction as moderate. Dicyclomine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and confusion. Anticholinergics may also slow gastric motility and modestly reduce the absorption of oral phenothiazines.
How serious is the interaction between Dicyclomine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in older patients, and for reduced antiemetic or antipsychotic effect. Avoid combining where other options exist in patients with glaucoma, ileus or urinary retention.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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