Drug interactions
Difelikefalin + Propofol
Severity: Moderate
Difelikefalin and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and propofol is a potent sedative-hypnotic. Concurrent use may increase sedation, although difelikefalin is a peripherally restricted kappa agonist with limited central penetration.
What this interaction means in plain words
Difelikefalin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects from kappa-opioid agonism and GABA-A potentiation.
What to do
Titrate propofol cautiously and monitor level of sedation and respiratory status. Counsel patients about additional drowsiness after procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Propofol?
MediHelp rates the interaction as moderate. Difelikefalin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and propofol is a potent sedative-hypnotic. Concurrent use may increase sedation, although difelikefalin is a peripherally restricted kappa agonist with limited central penetration.
How serious is the interaction between Difelikefalin and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor level of sedation and respiratory status. Counsel patients about additional drowsiness after procedures.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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