Drug interactions
Difelikefalin + Vilazodone
Severity: Moderate
Difelikefalin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness. Combined with vilazodone, additive sedation and dizziness may occur, raising fall risk.
What this interaction means in plain words
Difelikefalin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Vilazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and dizziness, especially in dialysis patients prone to falls. Counsel on caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Difelikefalin and Vilazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Vilazodone?
MediHelp rates the interaction as moderate. Difelikefalin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness. Combined with vilazodone, additive sedation and dizziness may occur, raising fall risk.
How serious is the interaction between Difelikefalin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, especially in dialysis patients prone to falls. Counsel on caution with driving.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
